The LISM Laboratory (Laboratory for Integrative System Medicine ) was established jointly by IFC-CNR (Institute of Clinical Physiology) and IIT-CNR (Institute for Informatics and Telematics) in order to develop research in bio-informatics with applications in medicine, with particular emphasis on approaches "Systems Biology" and "Next Generation Sequencing" applied to the study of multifactorial diseases such as heart disease and cancer.

To propose advances in Quantitative Modeling and Computational Tools with relevance and impacts measurable at systems scale.

Such scale is becoming predominant in both biological and medical fields, due to the critical role played by next generation technologies and data-intensive applications.

Methods and Algorithms from Systems Theory, Bioinformatics, Mathematics, Statistics, Machine Learning, Information Theory, Networks, Signal Processing will be investigated to conduct analysis and inference at complex systems scales.